Liver Biopsy in Chronic Viral Hepatitis (B And C) and Autoimmune Hepatitis Referred to Shahid Sadoughi Hospital Yazd, Iran

Objective: To evaluate the liver biopsies of patients with chronic viral hepatitis and autoimmune hepatitis based on age, gender, clinical features with staging and grading of disease. Material and Methods: This descriptive study was conducted through case series and all patients who were positive for HBsAg or HCV Ab or autoimmune hepatitis, had liver biopsies and were assessed for staging and grading based on scheuer system. Data were analyzed using SPSS version 13 and chi-square test. Results: One hundred twenty patients were included in this study with 94 males and 26 females. Forty eight (40%) were HBsAg positive, 58 (48.2%) HCV positive, 16 (13.3%) autoimmune hepatitis and 2 had both B and C hepatitis. There was significant relation between HCVAb with gender (P:0.00), cirrhosis and age (P:0.006), cirrhosis and gender (P:0.00), staging of hepatitis with duration of clinical signs (P:0.000) and grading of disease (P:0.000), frequency of cirrhosis and beginning of clinical signs